5 was used to generate figures and summaries

For our secondary outcomes, we extracted the number of cases and the total sample size. The safety outcomes extracted from included trials were the number of patients reporting any adverse event, the number of patients reporting any serious adverse event (as defined by each study), the number of patients withdrawn from study because of adverse events, and the number of patients with abnormal results on liver function tests (hepatic enzyme activity 1.5 times the upper limit of the reference range). RevMan version 5.3.5 was used to generate figures and summaries.

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